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Cystic fibrosis and trisomy E syndrome are two of many diseases or syndromes in which unusual cries are part of the diagnosis.Click on the links to listen to the explanations. Special thanks to the Montreal Children's Hospital for the audio files.

Solution to February 2011 Question of the Month

The question was:What are those little bumps on areolas? What’s their connection to chemistry?


In his voyage to the land of the giants, the so-called Brobdingnag, Gulliver does not exactly perceive breasts in a Hugh Hefner fashion:

The nipple was about half the bigness of my head, and the hue both of that and the
dug, so varied with spots, pimples, and freckles, that nothing could appear more nauseous.

What the clergyman-writer did not realize is that although breasts can have pimples, the areolar bumps that he was probably referring to were sebaceous glands. They secrete a fluid consisting of wax monoesters, triglycerides, free fatty acids and squalene, a terpene also found in shark oil. The Montgomery tubercles, a type of sebaceous gland, play an important role in breastfeeding. Secretions from these pregnancy-enlarged glands lubricate the breasts, protecting them from trauma and infection. Smooth muscle bundles are also found in these glands, which extend into the tips of the breasts. If it were not for those variations that Swift found unappealing, nipples would not pucker up in the cold and would not become erect in a state of arousal.

Sebum, the mixture of fats released by sebaceous glands, is found in all mammals, and so it also serves to lubricate hair. The exact composition varies among species, but there is one fatty acid that is only released by humans. Appropriately enough, it is called sapienic acid(the “be wise”acid, as in Homo sapiens).

 Is there any way that the total number of double bonds and structural rings can be predicted from its molecular formula of C16H30O2?

Use the formula 1+C–H/2 = the index of unsaturation, where C = number of carbons in the formula; H = number of hydrogens in the formula.
Notice that if the compound contains oxygens, they are ignored. For every nitrogen atom, one hydrogen has to be removed before plugging in the number of hydrogens. Finally, each halogen is replaced with hydrogen.

In this case, 1+16 -30/2 = 2. And there are indeed two double bonds in the structure of sapienic acid.

Solution to March 2011 Question of the Month

If we heat a flask of water to 50oC in a 20 oC room, and the water's temperature drops by 5oC in one hour, in the next hour its temperature will drop by less than 5oC. That's because the rate of heat loss is proportional to the difference in temperature between the hot object and its surroundings. When I first heard of the idea, it made me realize that placing a conventional fanless radiator under a window is a bad idea: as the heat rises towards the cold window, it creates a larger gap in temperature,leading to a higher rate of heat loss.


I came across a fictional but cute problem involving this so-called Newton's Cooling Curve, mathematically represented by


Dt= time in hours elapsed between Ti and Tf

Ts = temperature of surroundings

Ti = initial temperature of dead body

Tf = final temperature of dead body


It's from http://www.ncsec.org/team3/teachers/corpse.html.

Holmes and Watson were called to the scene of the murder by Inspector Lestrade of the police.  The victim was a wealthy but cruel man.  He had many enemies.
The most likely suspects are the wife, the business partner, and the butler.  Each has an equally strong motive.  Each also has an alibi.  The wife claims to have spent the entire evening at the theater across town.  She was seen leaving the theater at 10:30 p.m. and returned home at 11:00 p.m., going straight up to her bedroom.  Her return was verified by the upstairs maid.  The business partner claims to have spent the evening working on papers at the office.  His wife and household staff verified that he returned home at 10:30 p.m.  The butler was on his night off.  He claims to have been at the local pub until 10:00 p.m.  The butler returned to his quarters above the carriage house at 10:05 p.m. and did not leave.  This was verified by the other servants.
The body was found in the victim’s study.  Holmes arrived at the scene at 4:30 a.m.  The room was unusually warm and stuffy.  One of the police officers went to open a window.  Holmes admonished him to delay that action until he had completed his investigation of the crime scene.  He instructed Watson to determine the temperature of the body.  This was found to be 88.0°F.  Holmes questioned the servants as to the room temperature during the evening and learned that the man had liked the room warm and that the temperature in the study was always very near the current 76.0°F.  Holmes asked Watson to take the temperature of the body again at the conclusion of his inspection of the scene, two hours after the first reading.  It was 85.8°F.
How long had the body been dead? Who among the suspects is the murderer?


First using Watson's data during the the two hour of body coolig, we obtain the cooling rate constant:


85.8-76.0=(88.0 -76.0) e-k(2.0)

9.8/12 = e-2k


ln 0.8166...=lne-2k


k=0.1012621321 per hour

Now using the cooling rate constant we obtain Dt ,the time the body has been dead by using the body temperature of the man when he was alive 98.6 F as the initial tmperature and the temperature at 4:30 AM as the final temperature.



(12/22.6)= e-0.1012621321Dt

0.53097= = e-0.1012621321Dt

ln(0.53097)= = ln e-0.1012621321Dt

-0.6330432565= -0.1012621321Dt

Dt =6.25 h

so tracing back from 4:30 AM, the man was kiiled at approximately 10:15 PM, when the wife was still in the theater and the butler was in his carriage house. The business partner was the only suspect that could have been at the murder scene.

Solution to April 2011 Question of the Month

Although morphine is highly addictive, it is a superb painkiller, making Tylenol seem like candy. Chemists have long attempted to modify its structure in an attempt to create something nonaddictive, but they have failed. Some of its cousins have turned out to be more powerful but more habit-forming or less potent altogether.

Examine the structure of some morphine derivatives and see if you can identify the four shared characteristics.

Morphine's Cousins


1. A tertiary nitrogen with a small alkyl substituent. This means that three carbon groups have to be attached to the nitrogen, with one of them being small.
2. A quaternary carbon.
(One carbom has to be attached to four other carbon groups. )
3. A phenyl group (six membered carbon ring with alternating double bonds) or its isosteric equivalent directly attached to the quaternary carbon.
4. A 2 carbon spacer between the quaternary carbon and the tertiary nitrogen.

It should be pointed out that some synthetic compounds still act as opiates, even though they do not adhere to the morphine rule.

Solution to May 2011 Question of the Month

At the time of writing(May 29) Boston's Bruins seemed poised to win the Stanley Cup. But there is far more to Boston than its quality sports teams. The bordering town of Cambridge is the most well-read city in North America, and the area features some of the continent's best colleges like Boston University where geologistMaureen Raymo has done soem controversial but thought-provoking work.

Here's a summary of her research from BU's web site:

Maureen Raymo studies the causes of climate change over Earth’s history, in particular the role played by the global carbon cycle and Earth’s orbital variations around the Sun. Most of her work is based on data collected from deep-sea sediment and microfossils recovered using the research vessel JOIDES Resolution. She uses the stable isotopes of oxygen and carbon to study past ocean circulation and ice volume history and is well known for her proposal that the cooling of global climate over the last 40 million years was caused primarily by enhanced chemical weathering and consumption of atmospheric CO2 in the mountainous regions of the world, especially in the Himalayas.

Why was her hypothesis that the formation of the Himalayas caused a great ice age controversial?


This interesting dialogue and insight into the controversy is from PBS Nova.

"Cracking the Ice Age"

PBS Airdate: September 30, 1997
Go to the companion Web site

ANNOUNCER: Tonight, on NOVA, trek to the top of the world on an expedition that's putting a bold new theory to the test. Hunt for clues in a chilling mystery.

MAUREEN RAYMO: Would you ever be able to find enough fossils and date them well enough —

ANNOUNCER: Do the Himalayas hold the key to the origin of the Ice Age? Did these mountains rise up and forever change the world's weather? Science takes a stab at cracking the Ice Age.

NOVA is funded by Prudential.

Prudential: insurance, health care, real estate and financial services. For more than a century, bringing strength and stability to America's families.

And by Merck.

Merck: pharmaceutical research, dedicated to preventing disease and improving health. Merck: committed to bringing out the best in medicine.

The Corporation for Public Broadcasting and viewers like you.

JAY GREGORY: The Himalayas are one of nature's finest masterpieces. Rising five miles into the sky, they are the highest and steepest mountains in the world. The creation of this magnificent landscape is one of the most dramatic tales in the Earth's history. Now, scientists believe that these mountains could hold the answer to one of the Earth's oldest mysteries: the cause of the Ice Age. The Earth formed about four and a half billion years ago in a violent inferno of rock and gas. Since then, the climate has almost always been hot. For hundreds of millions of years at a time, most of the land was lush, tropical forest. During these extensive warm periods, no ice seems to have existed anywhere on the planet, even at the poles. Punctuating this long record, though, are several mysterious cold spells, or ice ages, when vast portions of the Earth froze. The last ice age, probably the most severe of them all, started about forty million years ago. Around that time, as if the Earth's thermostat got turned down, temperatures gradually started falling. Eventually, it got so cold that immense icebergs cluttered the oceans. So much water was frozen solid that sea levels dropped about four hundred feet. Ice sheets, up to several miles deep, covered much of the Earth's surface. In the northern hemisphere, those ice sheets have been growing and retreating in fairly regular cycles for the last two and a half million years. Eventually, ice crept as far south as modern day Nebraska, Chicago and New York. About twelve thousand years ago, that ice sheet shrank away. Scientists think that changes in the Earth's orbit explain the repeated growth and retreat of these ice sheets. The greater mystery, though, is why it got so cold in the first place. What caused the long, slow, cooling trend after it had been warm for so long?

JOHN KUTZBACH: The Earth's climate has been warm for hundreds of millions of years. Then that Earth began to change. It began to get cooler, first slowly. By about forty million years ago, there was ice in Antarctica and in Greenland. It got colder still, and then almost in a twinkling of an eye, huge ice sheets began to form eventually reaching depths of well over a mile. Why did that happen?

JAY GREGORY: That question has baffled scientists for over a century. Answers to the ice age mystery have ranged from fluctuations in the sun's output to dust injected into the atmosphere by large volcanic eruptions. Even life, itself, all the animals, plants, and other organisms on Earth, is believed to help regulate temperature. Now, adding to that list, some scientists are proposing a geological explanation for the ice age. It is a controversial new idea that links changes in global climate to one of the Earth's most impressive geological features: the Himalayas. Even from space, these mountains stand out like a giant scar on the face of the planet. This is some of the most rugged and wrinkled terrain on Earth. To investigate whether the formation of these mountains somehow caused the ice age, an international team of scientists recently ventured to this remote corner of the world. The expedition began in the Himalayan city of Lhasa, the ancient capital of Tibet. Now controlled by China, Tibet lies just above India in the heart of Asia. On its southern edge are the Himalayas. To their north is the vast Tibetan Plateau, about one-third the size of the United States. Averaging more than fifteen thousand feet above sea level, the Tibetan Plateau is the highest terrain on the planet, the roof of the world. It is so remote that half the population of the plateau still pursue the traditional nomadic lifestyle of their ancestors. Scientists have long sought access to this region, but few have ever been admitted. Protected by the Himalayas, traditional Tibetan society always discouraged exploration by outsiders. Until recently, that society was organized around a Buddhist religious hierarchy, whose customs had remained unchanged for centuries. All that came to an end in 1949 when China invaded Tibet. A few years later, the Dalai Lama, Tibet's traditional leader, fled across the mountains to India fearing for his safety. As China tightened its grip, much of ancient Tibetan society was obliterated. This region is still severely restricted under Chinese Communist rule. The Tibetan Plateau remains virtually unexplored. Scientific expeditions to this part of the world are rare and only for the hearty. This one, in search of clues to the start of the ice age, would take more than two weeks to traverse about a thousand miles of the rugged Tibetan Plateau. The air at this altitude of 15,000 feet is thin, and even in the Summer, temperatures drop well below freezing at night. The scientists on this expedition included those who support the idea that the Himalayas caused the ice age, as well as some who are more skeptical. While the sights in this region are always magnificent, this team was here to do more than enjoy the scenery. For those who know how to read it, this landscape tells a story. It is a story of the birth of the Himalayas and of what happens when continents collide. The surface of the Earth is divided into huge moving plates. These plates separate at massive volcanic ridges the size of mountains on the sea floor. Magma from deep inside the Earth wells up between these ridges spreading outward and forming new crust. This process is known as sea floor spreading. It is happening all the time and accounts for about eighty percent of the world's volcanic activity. The continents were originally in very different positions than they are today. The plates are constantly in motion, and India and Asia were headed toward each other on a collision course.

NIGEL HARRIS: A hundred and fifty million years ago, I would have been standing on the southern edge of the Asian continent. And far away to the south, there would have been an ocean, the Tethys ocean, stretching for thousands of kilometers, and on the other side of that ocean, there was the Indian continent. Now plate tectonics dragged the Indian continent closer and closer towards the Asian continent.

JAY GREGORY: About forty-five million years ago, India crashed head on into Asia, but it didn't stop there.

PETER MOLNAR: Since that time, it has moved two thousand kilometers north, plowing up mountains in front. The most spectacular consequence of this collision between the Indian subcontinent and the Asian continent is the Himalaya.

NIGEL HARRIS: Here we can see strata which originally would have been laid down horizontal and now they've been deformed, they've been upturned, they've been folded, they've been totally scrunched about showing the impact of that major collision.

JAY GREGORY: As it crashed into Asia, the upper layers of the northern edge of India were sheared off and stacked up over the collision zone forming the Himalayan Mountains. India is still pushing underneath the Himalayas at about two centimeters a year, and as a result, the Himalayas continue to rise. On the other side of the Himalayas, this collision created the Tibetan Plateau. Year by year, while India moved north, it squeezed Asia upwards. At the same time, some of India also got forced down underneath Asia. Over millions of years, these forces raised the land from sea level to its present height of 15,000 feet. But what does the creation of mountains and plateaus have to do with the ice age? The idea that the two might be related came from an unlikely source: the ocean. While leading a scientific expedition at sea, marine geologist, Bill Ruddiman, unexpectedly became interested in Tibet.

BILL RUDDIMAN: For me, it all started with a cruise in the North Atlantic and we drilled through hundreds of meters of glacial material, and then suddenly you come to a point where there's no more glacial material.

JAY GREGORY: Ruddiman was working aboard this ship drilling long thin cores of sediment out of the bottom of the ocean. Scientists use these cores to study the Earth's climatic history. Trapped within the cores are the fossilized shells of tiny creatures that lived in the water millions of years ago. These creatures used the elements in the ocean to build their shells. The make-up of the water changes with variations in climate, so the composition of their shells reflects the temperature of the time in which they lived. By comparing the shells from different layers in the ocean floor, scientists can tell when it was warmer and when it was colder, building a record of temperature. Ruddiman had drilled down to the time before ice sheets crept onto North America. Now he found himself wondering why it had become so cold that these ice sheets could form.

BILL RUDDIMAN: There comes a time about a year later when you have to, if you're co-chief, you have to write up a synthesis of your results. You list what you found and then you take a stab at what's going on to explain it.

JAY GREGORY: To do that, Ruddiman began looking for other changes in the Earth that might have caused the climate to cool down.

BILL RUDDIMAN: Coming into the literature at that point was evidence for uplift of Tibet. That's a big change because Tibet is a huge feature, so creating that over the last forty million years, but creating a lot of it in the last ten million years is a big change.

JAY GREGORY: But did the creation of the Himalayas and the Tibetan Plateau actually cause the ice age, or was it just an unrelated coincidence? Ruddiman decided to investigate.

BILL RUDDIMAN: I was thinking that we might make a major contribution to solving the problem, the beginning of glaciation, partly because uplifted terrain gets cooler and partly because it turns the winds in such a way that for instance there's a more northerly flow into North America, into the area where the glaciers grew. So it was a reasonable assumption that it might help promote glaciation.

JAY GREGORY: Ruddiman began by looking at the way wind blows across the region. The mountains and plateau interrupt its smooth flow, forcing it to the north. Over the rest of the northern hemisphere, this increases wiggles or meanders in the jet stream, the higher level winds that blow west to east across the globe. In North America, this brings cooler air from the Arctic further south. Ruddiman wondered if this influx of cold air caused the ice sheets to grow.

JOHN KUTZBACH: When Bill came along with the idea that perhaps mountain uplift was changing the wind patterns in the planet in a way that would promote glaciation in high latitudes, bring cold arctic air further south, this was an exciting idea to me.

JAY GREGORY: To help him figure this out, Ruddiman turned to climatologist John Kutzbach.

JOHN KUTZBACH: What I want you to think about is this is a continent, and this is the Indian Ocean. And if we had a low lying continent of this form, you might get a very weak convection cell with rising air, spreading out in the upper atmosphere and then air coming in from the surrounding ocean, perhaps producing a little bit of rain along the edges of the continent. But it just wouldn't be a very exciting circulation, because there's nothing on this continent to really focus the heating of the sunlight. If instead, we place a high plateau on a continent such as this, all of a sudden the sunlight during the summer time has a real focal point for heating this high plateau. So you have very more active currents of air rising over this plateau, spreading out, sinking, and air literally rushing in towards the continent. In addition to the air coming in towards the continent, the spin of the Earth makes the air more or less spiral in, air coming in off the Indian Ocean, spiraling in over the continent, banging into the Tibetan Plateau, being forced to ascend, producing violent thunderstorms along the face of the plateau. It's easy to understand if you've been in a mountainous climate that mountains effect the air flow and local thunderstorms. But what surprised us was that the effects extended far beyond the Tibetan Plateau, itself.

JAY GREGORY: Looking at what might have happened at the time the Himalayas were created, Kutzbach used a computer to simulate weather patterns under three different conditions. First, with no elevation in the area; second, with the Tibetan Plateau at half its present height; and third, with the plateau at today's elevation of more than 15,000 feet.

JOHN KUTZBACH: We've got this box outline where the Himalayan Mountains and the Tibetan Plateau are, so you can have that for reference. Then the coloring on here shows the rainfall patterns in the Summer time on a world, like our present world, but without the Tibetan Plateau. And you see that there's just a little bit of rainfall here in southeast Asia and over in Africa. Now if we advance this to our experiment with half mountains, you see that things are beginning to happen. The region of high rainfall has increased over all of southeast Asia and spreading up onto the Tibetan Plateau. And then if we go to the full mountain simulation, there's even a more dramatic change, very heavy precipitation on the south and southeast corner of the Tibetan Plateau, over southeastern Asia and a very large dry area extending from the Middle East into the Mediterranean and North Africa.

JAY GREGORY: The computer model was remarkably accurate at predicting the climate patterns in the region today.

JOHN KUTZBACH: It does give you a feeling of power, almost like playing God to be able to say to the mountains, "Rise up." And so you crank up the height of the mountain from one experiment to another and then it's really exciting to sit back and say, "Oh, what have we done? What do these changes produce?"

JAY GREGORY: What these changes produced was a stronger Asian monsoon system, perhaps ten times stronger than without the mountains. The uplifted land blocks the flow of air from the Indian Ocean and the moisture in that air falls out as rain over southeast Asia. The world's heaviest precipitation, as much as four hundred inches of rain, falls on the southern slopes of the Himalayas.

BILL RUDDIMAN: I remember with, still with a sense of delight, sitting in my office and we took the results from the model and I came to a, just a very different realization as to how beautifully the uplift of Tibet changes the distribution of moisture, where it's wet, where it's dry, which season it's wet or dry in, and so it actually puts the deserts into the places deserts are, and puts the rain forests in the areas that rain forests are. It doesn't explain everything on the face of the Earth, but it has a major effect on the patterns of wet and dry climate and vegetations not just on the plateau, but well around the plateau upstream and downstream.

JAY GREGORY: The computer model showed climate evolving over time as a result of changes in the elevation of the Tibetan Plateau. Now they needed to find hard evidence to prove it. Maureen Raymo, then a graduate student working with Bill Ruddiman, helped with his search.

MAUREEN RAYMO: At the same time they were doing the experiments, putting in the half plateau, taking out the plateau completely and seeing what changes in atmospheric circulation there were, at the same time they were doing that, we were doing this vast literature search of how climate had changed in the northern hemisphere over the time interval that the uplift was happening.

JAY GREGORY: Plants are reliable indicators of climate at the time and place they grow, whether it is wet or dry, warm or cold. Scouring the records of previous scientific expeditions, Raymo and her colleagues traced changes in plant life during the millions of years that the Himalayas were forming.

MAUREEN RAYMO: You know, some plant here said this place got dryer and some plant here said that place got colder, and it was just amazing how well all the predictions of the model matched.

JAY GREGORY: But the computer model of the climate of the Tibetan region had one major drawback: it revealed that Tibet's impact on air circulation was just not strong enough to produce the ice age.

BILL RUDDIMAN: The results of the model ended up explaining a little bit of almost everything except what we were after. There was really a very small cooling of the Arctic area and the areas where ice sheets must grow.

MAUREEN RAYMO: Just putting the plateau in the models didn't really cause any like major global cooling, like you couldn't explain why Antarctic ice sheet grew. So it seemed like there still was some other cause for global cooling. This was something that I was always thinking about, and that was the whole reason I went to graduate school, I wanted to study climate change, and in particular, why the northern hemisphere ice ages started.

JAY GREGORY: The main component of climate change is a mechanism called "The Greenhouse Effect." The amount of carbon dioxide in the Earth's atmosphere controls its temperature. Carbon dioxide traps heat from the sun. If the level of carbon dioxide increases, more heat gets trapped and the temperature rises. If carbon dioxide decreases, more heat escapes and the temperature falls. But what controls the level of carbon dioxide in the atmosphere? Most carbon dioxide enters the atmosphere by volcanic activity and sea floor spreading. In the air, carbon dioxide combines with rain water, making a weak acid that erodes rock. This chemical reaction remove carbon dioxide from the atmosphere. The dissolved carbon then washes into the oceans where organisms use it to make their shells. When they die, they settle to the bottom forming the ocean floor. As sea floor spreading occurs, sediments on the ocean floor get dragged down and heated, releasing carbon dioxide. Then the process, known as the carbon cycle, starts all over again. One of the first to investigate how the carbon cycle influences global temperature was geochemist, Robert Berner.

ROBERT BERNER: I've been working on the whole problem of carbon and sediments for a very long time, maybe thirty years. But the, actually doing modeling of the carbon cycle, we started thinking about the problem around 1980.

MAUREEN RAYMO: It was just an amazing model. I read the paper many, many times. I thought it was just so neat to think about climate this way.

JAY GREGORY: According to this model, climate is largely controlled by how much carbon dioxide enters the atmosphere from sea floor spreading. If sea floor spreading speeds up, the Earth releases more carbon dioxide and the temperature rises. If sea floor spreading slows down, then less carbon dioxide enters the atmosphere and the temperature falls.

ROBERT BERNER: The real benefit of studying these models is to evaluate the different processes that effect carbon dioxide, how you circulate carbon from one part of the surface of the Earth to another, and to the depths of the Earth. And we can learn more about geological processes by studying the carbon cycle, as well as trying to get at, the goal of course is trying to get at what controls carbon dioxide over geologic time.

MAUREEN RAYMO: It was a model that explained long term climate change over the last hundred million years as a function of CO2 in the atmosphere, Greenhouse Effect Hypothesis.

ROBERT BERNER: So we think perhaps there's some correlation between our calculations and climate in the sense that low CO2 could have triggered glaciations by bringing about a reduced Greenhouse Effect.

JAY GREGORY: But Maureen Raymo thought she saw inconsistencies in the model.

MAUREEN RAYMO: One of the things about the model that didn't jive was there seemed to be this mismatch between what the model predicted and what really happened in geologic history.

JAY GREGORY: The model did not accurately predict the cooling of the last twenty million years. Perhaps another factor was helping to control the level of carbon dioxide in the atmosphere. Raymo thought the Himalayas might provide a clue.

MAUREEN RAYMO: These mountains are just falling apart.

JAY GREGORY: The rocks that make up the Himalayas are constantly being eroded, both by geological forces and by chemical erosion. This occurs when carbon dioxide dissolved in rain water makes an acid and reacts with rock.

MAUREEN RAYMO: You can do two things to a rock: you can break it up and you can dissolve it. When you start dissolving it, what you're doing is taking, ultimately what you're doing is taking CO2 out of the atmosphere. CO2 in the atmosphere dissolves in rain water, makes a very dilute acid, and you know, attacks, etches the rock. And when it dissolves bits of the rock, the elements recombine to form new minerals and in the process, the CO2 that was in the atmosphere ultimately ends up in a carbonate rock. So basically the rivers are the conveyor belt, taking the carbon from the land to the ocean where it's effectively removed from the atmosphere.

JAY GREGORY: As the Himalayas grew, huge amounts of rock were exposed to the elements. The heavy monsoon rains combined with carbon dioxide in the air and eroded the rock. Could this process called chemical weathering take so much carbon dioxide out of the atmosphere that global temperatures would drop enough to trigger an ice age? Few scientists thought it could.

MAUREEN RAYMO: Generally in the textbooks that I was reading in the early '80s, it was kind of assumed that chemical weathering was a function of rainfall, land area, temperature, these factors. And according to this logic, you might think, you know, you would think that the Amazon rain forest, for instance, would have the most chemical weathering in the world because it had all of these factors. But one day I was sitting in a class, and one of the professors put up some numbers on the board, and one of them struck me as, these were numbers of river discharge of dissolved materials, so rock, dissolved material. And it was a very high number coming out of Southeast Asia and this area. And I started really digging into a lot of the recent literature. I realized that actually a lot of chemical weathering is going on in mountainous regions.

JAY GREGORY: Raymo wanted to find out exactly how much dissolved rock the rivers higher up in the Himalayas were carrying. Would it be enough to support her idea that these mountains helped bring about the ice age? For help in answering this question, Raymo turned to a colleague who specializes in collecting and studying water samples from all over the world.

JOHN EDMOND: You have to work in pristine systems because what you're trying to understand is how the world works as a chemical system, so you have to go to remote areas. Then the problem you get into is one, just a brute force logistics problem: how do you get there, how do you move around, how do you get out, what do you eat? And the second problem is there's no supporting information. That's to say, there won't be long records of the flow, which you need, there won't be long records of sediment transport, and there very often isn't a supporting information base of geology, vegetation type and even climate.

JAY GREGORY: Tibet is just such a place. Scientific field work here is still in its infancy. Weeks are spent getting to locations where data can be collected. But such distances seem short when compared to the travels of the nomadic Tibetan herders whose tribes have called the plateau home for centuries. For everyone on the road, meals are a simple affair: noodles and dried yak meat. Although the plateau is familiar territory to its inhabitants, its vastness is both exciting and frustrating to scientists.

MAUREEN RAYMO: There's huge areas of the plateau we know nothing about. It is ironic that it's playing such an important role in the science in the last few years and we know so little about it and have so little access to it.

JAY GREGORY: On this expedition, Raymo had the opportunity to collect water samples to learn how much weathering is going on here today.

MAUREEN RAYMO: It's going to be very interesting actually to start at the top of Tibet and go right through the Himalayas and see if there's any obvious change in the water chemistry as we go through those formations.

JAY GREGORY: Building a base of information about the region can be slow and tedious. Pinpointing the exact location where data comes from is difficult in unchartered places. But the process has gotten a lot easier in recent years.

MAUREEN RAYMO: We've just taken a river sample, and rather than writing it's you know it's so many kilometers from some town that has a different name on every map, what we're doing is getting a satellite fix. And this little piece of plastic has an antenna in it and twenty thousand kilometers above us, there's twenty-four satellites circling the Earth, and this usually can pick up about five. And what it does is it picks up an incredibly faint signal from those satellites and calculates, triangulates an exact position for this spot.

JAY GREGORY: After more than a week on the road, the expedition came to a temporary standstill upon reaching Mount Kailas in western Tibet. Tibetans from all over make pilgrimages to this sacred mountain, which they regard as the center of the cosmos. At least once in their lifetime, they hope to walk around Kailas, an act of devotion that helps accumulate spiritual merit. The team paused for its Tibetan members to make this journey, a hike of about eighteen hours straight. Afterwards, the expedition could begin again. For Raymo's explanation of the ice age to be taken seriously, it would have to be backed up with hard data. What she needed was a way to show that weathering of the Himalayas had consumed so much carbon dioxide that global temperatures dropped. By accident, she stumbled on a piece of compelling evidence. It comes from a laboratory where scientists analyze sea floor sediment from the last eighty million years. One element they search for is Strontium.

DON DEPAOLO: Once we get our hands on the samples, we need really only take that material and drop it in some acid to dissolve it and then we can take the dissolved sample which because it's calcium carbonate really only has two major elements in it, it has calcium and strontium and we take the dissolved liquid, pass it through an ion exchange column which separates the calcium from the strontium and we end up with a little white spot in the bottom of a teflon beaker which is pure strontium.

JAY GREGORY: There are several types, or isotopes, of strontium, each with a different atomic mass. They can be separated in the lab and the concentrations of the different isotopes in each layer of the sea floor can be measured. A heavier variety called strontium 87 comes from the land and is washed into the sea by chemical weathering of rock. The lighter variety, strontium 86, comes from deep inside the Earth and is released by sea floor spreading. Maureen Raymo reasoned that by comparing the amounts of the isotopes in the layers, she would learn which process was more active at any point in time, sea floor spreading or chemical weathering. This curve graphs the ratio of the two isotopes, strontium 87 to strontium 86, over the last eighty million years. Here was a measure of which mechanism was more powerful in controlling levels of carbon dioxide in the atmosphere.

DON DEPAOLO: What we found as we got further into the strontium work was that the curve got more and more interesting. The problem was we weren't exactly sure what it meant. Now, it also turns out that about the same time, Maureen Raymo had, and Ruddiman, had come out with their ideas about how the Himalaya and the erosion of the Himalaya were effecting the Earth's climate and they in fact used the strontium data as evidence that erosion and weathering rates were changing, and this was support for their ideas. From about eighty million years ago to thirty-five million years ago, almost nothing happened. And then at thirty-five million years ago, wham!, the strontium curve starts to go up like a rocket in comparison. So if one was going to make a dividing line and say, "When was it the way it used to be, and when did it start becoming like it is now," in other words, "When was the Earth warm, and when did it start to get cold?", it would have been thirty-five million years ago. The strontium record was shouting that. If you stretch it a little bit, it's close to the time that India and Asia start to collide and one starts to build the Himalaya.

JAY GREGORY: But is the sudden increase in strontium 87 washing into the ocean at the same time the Himalayas were forming more than coincidence? Maureen Raymo sees it as an important piece of evidence supporting her ideas.

MAUREEN RAYMO: The strontium record is kind of the third piece of the puzzle, I guess, that fell into place. It kind of made it all click. One was, you know, I knew the history of the uplift of the Himalayas, I knew there was a lot of chemical weathering going on here today, but I didn't really have any, I, you know, I didn't really have a really good geologic record of how chemical weathering had changed through time. And when I saw a strontium isotope curve for the first time, I saw it at a meeting, and I realized that this was kind of, you know, the smoking gun, so to speak.

JAY GREGORY: The strontium curve is controversial, though. Not everyone agrees on what it actually means. Critics point out that the rising amount of strontium 87 may not be due to an increase in chemical weathering. It could be rising simply because more rocks rich in strontium 87 happened to become exposed on the surface of the Himalayas. In fact, such rocks are plentiful in the region.

NIGEL HARRIS: The granites formed in the Himalayas are exceptionally high in 87 strontium. So what we've got here is a ready source available at the surface to provide the increase in 87 strontium seen in the oceans.

JAY GREGORY: The strontium evidence remains open to interpretation. But another clue to solving the mystery of Tibet's role in the ice age may lie just a few day's drive away. In a small town on the Tibetan Plateau, the team met up with some local geologists and fossil hunters who had found a rock that they thought might be helpful.

PETER MOLNAR: Where'd you get this Laupan? Where did you get this?

KENNETH HSU: He says he find it in the tertiary basin north of Daezhing in the Kailas.

PETER MOLNAR: In the Kailas area?

KENNETH HSU: He say originally he thought it might be a stem of a plant, but now he compared that with the fossils which have been collected. And this one has been identified as a reed growing on the side of a river bank.

JAY GREGORY: A fossil plant, such as a reed that grew by the side of a river bank, reveals what the climate was like when the plant was alive. A comparison to the same area today reveals how conditions have changed. With enough plant fossils, scientists can build a record of these changes over time. This could help settle another mystery: exactly when did the uplift of the region occur and how quickly? The answers to these questions are vital to linking the Himalayas to the ice age.

MAUREEN RAYMO: What we really want to know is what the elevation history of the Tibetan Plateau is. And one of the ways that we think we may be able to get at this is using paleobotany. The idea behind this idea is when you climb up a mountain, you go through progressively different vegetation bands, obviously it's a lot colder at the top of the mountain, the vegetation's very different. And so possibly what we can do is look at fossils of past plants that are very high up on the plateau and try to infer what the elevation of those plants were at the time that those plants grew. So for instance, an extreme case, you'd find a palm tree at five kilometers, and that palm tree is Miocene, fifteen million years ago, does that mean that fifteen million years ago the plateau was, you know, much lower, at sea level, where palm trees grow?

JAY GREGORY: But can you really distinguish warm weather plants from cold weather plants in the fossil record?

PETER MOLNAR: If you look at tropical plants, the leaves are generally thick, they're often large, their margins are very smooth, these are called entire margins. Whereas if you look at temperate plants, often the leaves are thin, which is difficult to record in the fossil record, but their margins are often irregular, not all of them, but often irregular. They have teeth on the margins, that go around, teeth around the edge. You think of a maple leaf or an oak leaf, you have teeth around the edges. That's, those are parameters that we would measure.

MAUREEN RAYMO: Will you ever be able to find enough fossils and date them well enough—

PETER MOLNAR: OK, OK. No, no, that's another question, that's another question.

MAUREEN RAYMO: No, that's a critical question.

NIGEL HARRIS: But just a minute, we're in the middle of Tibet now. Is this going to work for us? Is this going to establish at what time the altitude of Tibet was at what level?

JAY GREGORY: Altitude is one problem. Temperature is another. Both are essential to understanding whether the uplift of the Tibetan Plateau caused the ice age.

NIGEL HARRIS: I see no reason why we shouldn't be able to trace back in Tibet over the last twenty million years or whatever, the variations in temperature. How we translate that into variations in altitude, that's a matter for debate. But as a method for predicting variations in temperature, it seems very powerful indeed.

PETER MOLNAR: Well, I personally think it's the only way. And, it won't work, indeed, if there are too few species represented. Six is not enough. We need twenty, twenty is a rough minimum. Whether there are enough fossil localities, that's a good question.

JAY GREGORY: To develop a reliable record of the history of the region's elevation by this method would require a wide range of plant fossils. Because this area is so inaccessible, many years and many more expeditions would be required. Field work in these conditions is never easy. The roads are notorious for contributing to the slow pace of science. And it is not just the views that leave visitors short of breath. Working at 15,000 feet is debilitating. Despite how much basic information has yet to be discovered about this region, Maureen Raymo remains steadfast in her opinion that the Himalayas caused the ice age.

MAUREEN RAYMO: The Himalayas are unique because they're so huge, they're so high, so much crest has been thrust up into the atmosphere, so much of it has been eroded that an enormous amount of mechanical and chemical weathering has gone on in this mountain range. It's like a huge sponge pulling CO2 out of the atmosphere. I think these mountains are in large part responsible for all of the global cooling of the last forty million years.

JAY GREGORY: With the addition of the strontium evidence, Maureen Raymo thought she had solved the ice age mystery. First, the uplift of the Tibetan region intensified the Indian monsoon. Then the monsoon rains eroded the mountains, stripping carbon dioxide from the air. Finally, with less carbon dioxide, the atmosphere got colder and colder. The only thing left to do was publish the idea.

MAUREEN RAYMO: I went back home and like wrote a paper. The paper was an agonizing ordeal, but I went back home and just started writing it. It was short, to the point.

JAY GREGORY: Some scientists loved it. Others were less enthusiastic.

ROBERT BERNER: The original paper by Raymo and co-workers in 1988 specified that if we had uplift of the Himalayas that the carbon dioxide would be consumed by weathering and the CO2 would go down. Well you can't just do this simply because you have to watch out. You'll run out of CO2 very quickly.

BILL RUDDIMAN: The geochemists are an unruly bunch. They have sharp knives and if you're wrong, you can be, it can be a very public matter.

MAUREEN RAYMO: There was a lot of things in that paper that were very controversial.

DON DEPAOLO: I think there's good reasons for why the reaction is mixed. I mean on one hand, I think some people think, "Well, gee, could it really be that simple and I missed it?" Or, the other thing is, "Well, she can't know enough about this to really get it right, so we are justified in not paying attention to it." But the fact is that it tweaks everybody.

MAUREEN RAYMO: I mean one of the people that was on my thesis committee just basically said the paper was unpublishable crap, you know? So I mean I got a lot of conflicting advice on that paper. Some people said, "Oh, this is great." Other people said, "This is a crock."

JOHN EDMOND: Scientists are men, unfortunately, usually men in white coats seeking after truth about one percent of the time. The rest of the time they're like everybody else. And so if you spent the last ten years making more and more elaborate models or experiments, whatever, it's not just modelers, and somebody comes along and says, "That's all by the way because you're not addressing this, and this is what's really the big problem," then the response isn't openhanded enthusiasm.

DON DEPAOLO: There's something about it that's undeniable, and that is that if you erode continental rocks, you should take away CO2 from the system. And if you look at the geologic record, there's been a lot of erosion in the Himalaya, and I don't think erosion was there before the Himalaya formed. So there's been some change since they came up. But if you look at the other models for how the climate system works, they're almost completely at odds with this idea, and there's a real scientific problem. So on the one side, there's, if you listen to Maureen, she will tell you a story that you have a hard time arguing with. And if you go to another person, for example, Bob Berner, he will tell you a story that's almost completely at odds with what Maureen will tell you, and give you good reasons why that has to be the case. And so we have a problem.

MAUREEN RAYMO: Things are definitely not perfect with my theory, there's major areas where I don't have an answer. But I think that, you know, that I'm going in the right direction. And I think I know what the problems are and how to go about trying to solve them. She says, hopefully.

JAY GREGORY: Raymo and her colleagues have added to the possible explanations of the ice age. But the mystery is far from solved.

PETER MOLNAR: If you put up a theory with no facts, it probably doesn't effect anybody, it just gets ignored. And she, of course, has not done that. She's got a lot of facts to back it up. But we still have a ways to go. Science, the forefront of science is a very fuzzy, fuzzy area, and one needs a balance of all kinds of approaches. There have to be ideas drifting around, they have to be formulated and worked up well and usually when they are, there still aren't enough facts.

JAY GREGORY: So while scientists continue to accumulate facts that tell us about our climate's history, some cannot resist speculating about its future.

DON DEPAOLO: If I was asked about what the climate was likely to do in the future, I would probably focus on the last two million years of the strontium curve, during which time the strontium ratio has gone up at a rate that's as close to as fast as it's ever gone up. And in the past when that's happened, it's meant that the climate is going to get colder in a couple of million years. So my prediction would be that we haven't seen the most intense ice ages yet.

BILL RUDDIMAN: It'd be a heck of a story if it turned out to be true.

ANNOUNCER: The highest plateau, the deepest canyon. Take on Tibet's extremes of land and weather at NOVA's website. Log on to pbs.org. Educators can order this show for $19.95 plus shipping and handling by calling 1-800-949-8670. And, to learn more about how science can solve the mysteries of our world, ask about our many other NOVA videos.

NOVA is a production of WGBH Boston.

Solution to June 2011 Question of the Month

The question was: Alcohol is now considered a class 1 carcinogen. Does that make it as dangerous as other proven human carcinogens such as benzene and heavy cigarette smoking?


Some of the connections between alcohol and some forms of cancer have been made only for moderate to heavy drinking of hard liquor, and the increased incidence of cancer for those exposed to high concentrations of alcohol is not as great as it is for heavy smoking or for regular exposure to small amounts of benzene. The same applies to any suspected carcinogen. It's a question of what dose is dangerous and of probability that cancer will arise.

Dr. Rachel Thompson, Science Programme Manager at the WCRF(World Cancer Research Fund) says, “If you are drinking a pint of lager or a large glass of wine everyday, then this might not seem like a lot.” She further added, “But the science shows you are increasing your risk of bowel cancer by 18 percent and your risk of liver cancer by 20 percent.”

In contrast here are the risks of lung cancer( just one of the many cancers that can arise)from smoking:

It was found that 172/1,000 of male current smokers will eventually develop lung cancer; the similar probability among female current smokers was 116/1,000. For those who never smoked on a regular basis the lifetime risk was substantially reduced. Only 13/1,000 males and 14/1,000 females in this category will develop lung cancer.

172/13 = 57 times more likely= that's a lot more than 18-20%!

References: http://www.ncbi.nlm.nih.gov/pubmed/7895211


Solution to July 2011 Question of the Month

The question was: Suspended silt in glacial lakes gives them a beautiful turquoise color. But what if the water was completely stripped of all its particles and any possibly colored ions, would it be as colorless as a glass of water apparently is?


See my essay in Science 2.0.


Solution to August 2011 Question of the Month

The question was: What experiment provided evidence for the idea that DNA replicates itself by unzipping and making a copy of each strand?



See my article in Science 2.0.

Solution to September 2011 Question of the Month

Is there such a thing as a chemical that can quickly break down otherwise persistent pollutants?


Yes in the last 10 years scientists have been developing TAMLs, which help hydrogen peroxide oxidize tougher molecules more quickly. To learn more see Science 2.0.

Solution to October 2011 Question of the Month

Does cooking vegetables destroy their vitamins?


The extent of vitamin loss through heat, oxidation and leaching varies with the vegetable and with the type of cooking method.To learn more see my article in Science 2.0.

Solution to November 2011 Question of the Month

Lactose intolerance, the inability to digest milk sugar,is more complicated than it seems. Does a given person only fall under one of only two categories: tolerant or intolerant?


Science 2.0 Article On Lactose Intolerance


Solution to December 2011 Question of the Month

Is there any evidence supporting homeopathy?


Science 2.0 Article On Homeopathy